Due to the absence of specific plot details or character information related to LGBTQ+ themes in the provided data, a comprehensive evaluation of the film's portrayal is not possible. There is no evidence to confirm the presence or absence of such depictions within the narrative.

Currently, there is not enough information available to assess the presence or portrayal of transsexual characters or themes in 'Agent, 2017'. Without plot details or character descriptions, it is impossible to determine any potential positive, negative, or neutral impact on the film's overall message.

The film features Agent Marikah, a skilled operative who participates in action sequences. However, available information does not describe any scenes where she defeats one or more male opponents in direct physical combat, such as hand-to-hand or melee weapon fights.

Without information on source material, previous adaptations, or historical context for 'Agent, 2017', it's impossible to determine if any character's gender deviates from a pre-established canon.

The film "Agent, 2017" is an original production with no indicated source material or historical figures. Therefore, its characters do not have a pre-established race from prior canon or history, making a race swap impossible by definition.