Dhurandhar features no transgender characters or themes. The narrative centers on a spy thriller involving infiltration and gang wars, with no elements addressing transsexual identity or experiences.

Female characters, including Yalina Jamali and Ulfat, serve in supporting capacities emphasizing emotional depth and dramatic confrontations, without participating in or prevailing in close-quarters physical combat against male opponents. Action sequences center on male leads in espionage and gang conflicts.

Dhurandhar presents an original spy thriller with fictional characters loosely inspired by real events and figures, all portrayed with matching genders and no alterations from canonical or historical baselines.

Dhurandhar draws from real South Asian intelligence operations and figures like Ajit Doval, Chaudhry Aslam Khan, and Rehman Baloch, all depicted by South Asian actors in roles matching their racial backgrounds, resulting in no race swaps.