Die Beautiful provides a profoundly affirming and empathetic portrayal of a transgender woman's life, celebrating her identity, dreams, and chosen family. It depicts LGBTQ+ characters with dignity and complexity, framing external obstacles while ultimately validating the worth of queer lives and love.

Die Beautiful provides a predominantly positive and affirming portrayal of transsexual characters. The film centers on Trisha Echevarria, a transgender woman whose life, struggles, and triumphs are depicted with dignity and complexity. Despite external prejudice and a tragic death, the narrative celebrates her identity and agency, notably through her friends honoring her final wishes by presenting her as different celebrities during her wake.

The film portrays conservative Christian beliefs as a primary source of conflict and pain for the protagonist, Trisha, leading to her father's initial rejection and societal judgment. It critiques rigid interpretations that foster bigotry against LGBTQ+ individuals, presenting these interpretations as harmful and oppressive.