Guillermo del Toro's *Frankenstein* (2025) implicitly portrays LGBTQ+ themes through the Creature's story of otherness, transformation, and yearning for acceptance. The film uses this narrative as an empathetic metaphor for queer experiences, highlighting resilience, chosen family, and identity formation. Psychosexual undertones further suggest an exploration of fluid identity, resulting in a net positive and affirming thematic impact.

Victor Frankenstein, canonically established as a white European Swiss scientist, is portrayed by Oscar Isaac, an actor of Guatemalan-American and mixed Latin American descent. This casting represents a departure from the character's original racial and ethnic background, constituting a race swap.

The film uses Christian motifs and imagery, such as creation, Adam, and Satan, to explore complex themes of morality and identity through the creature's narrative. Director Guillermo del Toro's personal Catholic background and his interpretation of monsters as 'saints or messiahs' suggest a respectful and nuanced engagement with Christian concepts, rather than a critique of the faith itself.