The film offers an affirming portrayal of queer and trans allegories through the creature's story, emphasizing dignity, resilience, and the pursuit of unconditional love. Rejection by society and creator critiques external prejudices, while empathetic connections underscore the humanity and value of othered identities.

The monster embodies a trans-affirming allegory, its stitched-together form and quest for belonging symbolizing the struggles and resilience of trans identities against binary norms and exclusion. This portrayal validates the Creature's humanity through moments of tenderness and rage born of neglect, emphasizing external societal failures over personal deficiency.

Victor Frankenstein, canonically white in Mary Shelley's novel, is portrayed by Latino actor Oscar Isaac, constituting a race swap.

The film portrays family through cycles of abusive fatherhood and generational trauma, critiquing patriarchal parenting as a source of rejection and monstrosity while highlighting the need for compassion and accountability in relationships.

The film weaves Catholic imagery into Victor's blasphemous creation, portraying his hubris as a rejection of divine order that invites guilt and tragedy. It ultimately affirms Christian virtues through the Creature's messianic innocence and the narrative's emphasis on forgiveness and reconciliation between creator and created.