The film 'How to Lose Friends & Alienate People' does not include any discernible LGBTQ+ characters or themes. The narrative centers on the heterosexual protagonist's comedic misadventures in the world of celebrity journalism, with no exploration of queer identity or experiences.

This film does not feature any identifiable transsexual characters or themes. The narrative centers on a journalist's struggles and relationships within the high-society publishing industry, without engaging with transgender identity in any capacity.

The movie does not contain any action or adventure elements.

The film adapts Toby Young's memoir. Key characters, including the protagonist Sidney Young (based on Toby Young) and editor Clayton Harding (based on Graydon Carter), maintain their established male gender from the source material. There are no instances of characters canonically or historically established as one gender being portrayed as another.

The film is an adaptation of Toby Young's memoir. All major characters, whether based on real individuals or fictionalized, are portrayed by actors of the same race as established in the source material or real-world history. No race swaps are identified.