Label Me holistically portrays LGBTQ+ characters and themes through the journey of David, a young man grappling with his sexuality. The film depicts his complex path to self-acceptance and his romantic relationship with a drag queen, framing societal pressures as external challenges. The narrative maintains an empathetic stance, affirming the worth of LGBTQ+ lives and love amidst personal and external struggles.

Label Me sensitively portrays a romantic relationship between a cisgender man and a trans woman, depicting the trans character with dignity and agency. The film explores societal prejudices and personal struggles as external challenges, maintaining an empathetic stance. It ultimately affirms the worth of trans lives and love, as seen through the complex and respectful development of the central trans character, Sarah.

The film's narrative centers on an individual's exploration of sexual identity and non-traditional relationships within a chosen community, thereby normalizing sexual freedom and implicitly prioritizing chosen family structures over traditional biological family units.