Le crime d'une sainte portrays a transsexual character whose murder is presented as an external tragedy. The film affirms the character's worth through the mother's perception of her son as a 'saint' and her subsequent pursuit of justice, indicating an empathetic and validating narrative stance despite the tragic outcome.

The film's central premise, revolving around 'The Crime of a Saint,' strongly implies a critical examination of religious piety or institutional integrity. By depicting a holy figure committing a crime, the narrative likely challenges the perceived sanctity of the church or its adherents, highlighting hypocrisy or the oppressive nature of the religious environment that leads to such a transgression.