Love, Simon centers on a gay high school student's journey of self-discovery and coming out. The narrative exclusively explores themes related to gay identity and romance, without the inclusion of transsexual characters or related storylines.

The movie does not contain any action or adventure elements.

The film "Love, Simon" is an adaptation of the novel "Simon vs. the Homo Sapiens Agenda." All major characters in the movie retain the same gender as established in the original source material, with no instances of a character being portrayed as a different gender.

The film adapts a novel where some characters' races were specified and others were not. Characters explicitly described as Black in the novel are portrayed by Black actors. For characters whose race was not specified in the source material, their on-screen portrayal by actors of different races does not meet the definition of a race swap.