The film subtly introduces LGBTQ+ representation through Franklin Richards, whose pansexual identity from the comics is hinted at but not explicitly developed due to his young age. The portrayal is incidental, focusing more on family dynamics and broader gender politics rather than overt LGBTQ+ themes.

The film portrays the legacy role of the Silver Surfer, traditionally associated with the male Norrin Radd, with the female character Shalla-Bal. This constitutes a gender swap for the established character role.

Reed Richards, traditionally depicted as a white American in the comics, is portrayed by Pedro Pascal, an actor of Chilean-American and Latin American descent. This constitutes a notable shift in the character's established racial/ethnic background from its comic book counterpart.

The film's narrative strongly echoes Christian themes, particularly around sacrifice, the sanctity of life, and familial love, aligning with a pro-life message and virtues like sacrificial love.

Judaism is portrayed through Ben Grimm's attendance at synagogue, emphasizing the positive aspect of community and human relationships within religious practice, rather than focusing on spirituality.