The film "Mary and Max" includes explicit LGBTQ+ identities within its narrative. Max, a central character, identifies as asexual, a portrayal handled with directness and without judgment. A significant plot point involves Mary's husband revealing his homosexuality and leaving her, a narrative element that, while causing emotional pain, depicts his identity as a personal truth rather than a negative characteristic. The film integrates these identities without either uplifting or denigrating them.

The film explores the profound impact of dysfunctional biological families and the subsequent search for connection outside traditional structures. It emphasizes the importance of chosen family bonds as a primary source of support and belonging, contrasting with the failures of conventional family life.

Max, a central character, is Jewish, and his faith is portrayed as an integral part of his identity. The film treats his Jewish background with respect and empathy, aligning with the dignity of his personal experience.