Maze Runner: The Death Cure does not include any discernible LGBTQ+ characters or themes. The narrative is entirely focused on its dystopian sci-fi plot, with no elements that could be evaluated under an LGBTQ+ portrayal framework.

The film 'Maze Runner: The Death Cure' does not feature any identifiable transsexual characters or themes. Its narrative is centered on a post-apocalyptic struggle for survival and a cure, with no elements related to transgender identity or experiences.

Female characters like Brenda, Harriet, and Sonya participate in combat against male opponents, primarily WCKD soldiers. However, their victories are consistently achieved through the use of firearms from a distance. There are no scenes depicting them defeating male opponents in close-quarters physical combat, hand-to-hand, or with melee weapons.

As the third installment in an established film series based on novels, "Maze Runner: The Death Cure" maintains the canonical genders of all its major and recurring characters as depicted in the source material and previous films. No character originally established as one gender is portrayed as another.

All major characters in "Maze Runner: The Death Cure" maintain the same racial portrayals as established in the source novels and previous film installments. No character's race was altered from their canonical or established depiction.