The film "Mesrine: Killer Instinct" focuses on the life and criminal career of Jacques Mesrine. There are no identifiable LGBTQ+ characters or themes present within the narrative, which primarily explores Mesrine's relationships with women, his criminal exploits, and his escapes from justice.

The film "Mesrine: Killer Instinct" is a biographical crime drama that does not feature any identifiable transsexual characters or themes within its narrative. Consequently, there is no portrayal to evaluate regarding transsexual identity.

The film focuses on the life of Jacques Mesrine, a notorious French gangster. While female characters are present and involved in his criminal activities, none are depicted engaging in or winning close-quarters physical combat against male opponents. Their involvement in violent scenes is primarily through firearms or as accomplices.

The film is a biopic based on the real-life French gangster Jacques Mesrine. All major historical figures portrayed in the film maintain their documented historical gender, with no instances of a character's gender being changed from the source material.

This biographical film depicts real historical figures from 20th-century France. The cast accurately reflects the documented races of Jacques Mesrine and other key individuals, with no instances of a character's race being altered from historical records.