Mí is a mosaic drama featuring multiple intertwined stories of love and relationships in Madrid. The film includes a gay couple's narrative as one of its central threads, exploring their experiences within universal themes of love, sex, and loneliness. This integration into the broader human tapestry, without indications of problematic portrayal, results in a net positive and affirming depiction of LGBTQ+ lives and relationships.

The film portrays a transsexual woman, Lalá, as a central character navigating love, sex, and friendship alongside other diverse individuals. Her identity is presented with dignity and complexity, contributing to the film's broader theme of universal human connection and the search for happiness. The narrative avoids stereotypes, instead affirming the worth of her life and experiences.

The film centers on a young woman who confronts the ways her parents have shaped her life, with resurfacing childhood events underscoring ongoing parent-child conflict while her boyfriend offers external support.