The film does not feature any identifiable transsexual characters or themes. Its LGBTQ+ content primarily focuses on a character coming out as gay, which pertains to sexual orientation rather than gender identity.

The movie does not contain any action or adventure elements.

This film is a direct sequel featuring the same established characters from the original movie, all of whom maintain their previously depicted genders. No character from prior canon has their gender altered.

All primary and legacy characters in "My Big Fat Greek Wedding 2" maintain the same racial portrayal as established in the original film. The cast largely consists of actors of Greek or Mediterranean descent, consistent with the characters' established ethnicity and race. No character originally established as one race is portrayed as a different race.