The film "Myra Breckinridge" centers on a character's gender transition, but its portrayal is largely problematic. Myra is depicted as a predatory and manipulative figure, and the film's satirical tone often borders on mockery. The narrative concludes with Myra reverting to her former male identity, which contributes to a net negative impact on LGBTQ+ themes.

Myra Breckinridge portrays its transsexual protagonist, Myra, as a manipulative and sexually aggressive figure, using her identity primarily for extreme satire and shock. The film's tone often borders on ridicule, and its ending, where Myra reverts to her pre-transition identity, can be interpreted as a punitive outcome. Overall, the depiction lacks dignity and empathy, resulting in a problematic portrayal.

The film employs satire to critique traditional American morality and gender norms, which are implicitly rooted in Christian ethics. Through its transgressive protagonist, the narrative portrays these values as hypocritical, outdated, and repressive, offering no counterbalancing positive perspective.