Based on the information provided, there is no identifiable depiction of LGBTQ+ characters or themes in 'O Flagelo da Humanidade'. Therefore, the film's net impact on LGBTQ+ portrayal is rated as N/A.

Due to the absence of specific plot details or character descriptions for 'O Flagelo da Humanidade', an evaluation of its portrayal of transsexual characters and themes cannot be conducted. Consequently, the film receives an N/A rating, indicating no identifiable transgender content could be assessed.

The movie does not contain any action or adventure elements.

Information regarding 'O Flagelo da Humanidade' (1925) does not indicate it is an adaptation of existing material or features historical figures with pre-established genders. Without prior canon, characters are considered original to the film, precluding a gender swap.

This 1925 Portuguese silent film is an original production and not an adaptation of a work with pre-established character races or a biopic of historical figures. Therefore, no characters exist whose race could have been canonically or historically altered.