The film uses LGBTQ+ coded behavior and same-sex relationships primarily for comedic effect, often relying on stereotypes and shock value. While a same-sex marriage occurs, its context as an absurd plot resolution and the preceding jokes contribute to a net portrayal that leans into mockery rather than affirmation.

Saving Silverman features Coach Norton, a drag queen, whose portrayal is largely comedic and relies on the 'shock' value of his gender expression. The character is presented as a caricature, with humor often at the expense of his non-conformity, contributing to a negative overall impact regarding transsexual themes by endorsing mockery.

The film portrays Catholicism through Sandy, whose faith is depicted as sincere, compassionate, and a source of her inherent goodness. While her path to becoming a nun creates comedic conflict, the institution and its adherents are treated with respect, and the narrative ultimately affirms the dignity of her spiritual journey.