To Die For features Russell Hines, a character whose effeminate mannerisms and dependent relationship with another male accomplice are often interpreted as subtextually queer. However, the film does not explicitly confirm his sexual orientation, nor is this aspect central to the plot or the cause of his tragic end. The portrayal is incidental, neither affirming nor denigrating LGBTQ+ identity.

The film features Jimmy Emmett, a young man who cross-dresses. This aspect of his character is presented incidentally, neither central to the plot nor a source of mockery or affirmation. The portrayal avoids strong positive or negative arcs, treating his gender expression as a minor character detail rather than a significant theme related to transsexual identity.

The film portrays the Maretto family's Catholic faith as a source of traditional values and moral grounding, contrasting it with the protagonist Suzanne's ruthless amorality. The narrative condemns Suzanne's actions, implicitly affirming the decency associated with the family's faith.