To Sir, with Love centers on a new teacher's journey to inspire his challenging students in a London East End school. The film's narrative primarily explores themes of race, class, and education, without featuring any identifiable LGBTQ+ characters or themes.

The film "To Sir, with Love" does not feature any identifiable transsexual characters or themes. The story centers on a new teacher's experiences in an inner-city school, focusing on themes of education, social class, and youth development. There are no plot points or character arcs related to transsexual identity.

The movie does not contain any action or adventure elements.

To Sir, with Love is an adaptation of an autobiographical novel. The film's characters, including the protagonist and key students, maintain the same genders as established in the original source material. No characters canonically or historically established as one gender are portrayed on screen as a different gender.

The film "To Sir, with Love" (1967) features Mark Thackeray, a character based on the author E. R. Braithwaite, who was Black. Sidney Poitier, a Black actor, portrays Thackeray in the film. This casting aligns with the character's established race in the source material, indicating no instance of a race swap.