Uncle Frank centers on the journey of a gay man navigating his identity and relationships within his family and society during the 1970s. The narrative explores themes of hidden sexuality, acceptance, and prejudice related to being gay. There are no identifiable transsexual characters or themes present in the film's storyline, as exemplified by the focus on Frank's struggle with his homosexuality.

The movie does not contain any action or adventure elements.

Uncle Frank is an original screenplay, not an adaptation of pre-existing material or a biopic. All characters were created for this film, thus there are no instances of characters established as one gender in prior canon being portrayed as a different gender.

Uncle Frank is an original screenplay by Alan Ball, not an adaptation of a pre-existing work or a biopic. The characters were created for this film, meaning there is no prior canonical or historical race to be swapped from.