The film offers a positive portrayal of LGBTQ+ themes through Anybodys, a gender non-conforming character. Their struggle for acceptance is met with eventual validation and dignity, particularly from Valentina, affirming their worth within the gang and the narrative.

The film features Anybodys, a transgender male character, whose journey for acceptance within the Jets gang is depicted with dignity. Despite initial challenges, Anybodys proves their worth and is ultimately affirmed, contributing positively to the film's portrayal of transsexual themes.

The character of Glad Hand, a male social worker in the original musical and film, is portrayed as female in the 2021 adaptation, constituting a gender swap.

The film portrays Catholicism as a significant cultural and spiritual anchor for the Puerto Rican characters, particularly Maria, whose faith provides solace and moral guidance. While religious identity is intertwined with the ethnic conflict, the narrative does not critique Christianity itself, but rather the societal prejudice and violence between groups. The film's overall message aligns with the dignity of the faith as a source of strength for its adherents.