The film uses the mutant experience as a clear and empathetic allegory for LGBTQ+ identity, most notably through Iceman's 'coming out' scene. It critiques prejudice and affirms the worth of those who are different, resulting in a net positive portrayal.

The film features Mystique, who uses martial arts and agility to defeat multiple male opponents in close-quarters combat. This includes incapacitating Secret Service agents and Stryker's soldiers.

The film portrays Nightcrawler's Catholic faith as a source of his moral compass and inner peace, presenting it with respect and depth. While the antagonist Stryker misuses religious rhetoric to justify his hatred of mutants, the narrative clearly condemns his bigotry, positioning the audience to sympathize with the victims and affirm genuine faith.