American Horror Story consistently features prominent and complex LGBTQ+ characters who, despite facing immense horror and prejudice, are often depicted with dignity, agency, and resilience. The show frequently critiques societal injustices against queer individuals, affirming their worth even amidst tragic circumstances.

American Horror Story features Liz Taylor, a trans woman, whose arc is overwhelmingly positive. She is depicted with dignity, complexity, and agency, finding acceptance and love. The narrative affirms the worth of her trans identity, framing obstacles as external and celebrating her authentic self.

The show frequently depicts Christian institutions (e.g., Catholic Church in Asylum) and some adherents as corrupt, abusive, hypocritical, or easily swayed by evil. While individual characters may seek redemption, the narrative consistently highlights the oppressive and cruel aspects of organized religion without significant counterbalancing positive portrayals.