Due to a complete lack of available plot and character information for 'Big Mouth, 2022', it is not possible to determine if LGBTQ+ characters or themes are present, nor to evaluate their portrayal or net impact.

Currently, there is not enough information available to assess the film's portrayal of transsexual characters or themes. Without specific plot details or character descriptions, a determination of positive, negative, or neutral impact cannot be made. Therefore, no specific character arcs or story plots can be provided as evidence.

The movie does not contain any action or adventure elements.

Big Mouth is an original animated series featuring characters created for the show. There are no pre-existing canonical characters from source material, previous installments, or real-world history whose gender has been changed in this series.

The character Missy Foreman-Greenwald, established as biracial, was originally voiced by a white actress and later by a Black actress. This change aligned the voice actor's race with the character's established race, rather than altering the character's race itself. No other characters in the 2022 season had their canonically established race changed.