Cagney & Lacey featured early and notably respectful portrayals of LGBTQ+ characters. The show depicted a lesbian character with dignity and without stereotype, presenting her identity matter-of-factly and earning a positive net impact for its progressive stance in the 1980s.

The show features a transsexual character, Bobby, whose murder is investigated. The narrative critiques the prejudice she faced, framing it as an external societal issue. The detectives approach the case with empathy, affirming the worth of Bobby's life despite its tragic end, resulting in a net positive portrayal.

The series, known for its progressive social commentary, generally portrays Christian individuals and institutions with respect or nuanced understanding. While individual characters might be flawed, the narrative typically distinguishes between personal failings and the inherent dignity or virtues of the faith itself, often showing faith as a source of community or moral guidance.

Reflecting its New York City setting and commitment to social issues, the show likely depicts Jewish characters and communities with respect. If issues like antisemitism were addressed, the narrative would unequivocally condemn such bigotry, positioning the audience to sympathize with the Jewish community and affirming its dignity.