Control Z features multiple LGBTQ+ characters whose identities are central to their complex storylines. The series explores themes of self-acceptance, navigating relationships, and confronting prejudice with empathy and dignity. Queer characters are depicted with agency, and their experiences are integrated into the main narrative without being solely defined by their sexuality.

Control Z features a transsexual character, Bruno, who experiences transphobic bullying from a peer, Gerry. The series portrays Gerry's actions negatively, framing the prejudice as an external obstacle rather than an inherent aspect of Bruno's identity. The narrative maintains an empathetic stance towards Bruno, depicting the harmful impact of transphobia and condemning the bully's behavior. This portrayal affirms the worth of transsexual lives by critiquing prejudice.

The series consistently portrays traditional family structures as sources of dysfunction and secrets, with parental authority frequently undermined. The narrative normalizes alternative relationships and challenges conventional family norms.