Curb Your Enthusiasm includes various LGBTQ+ characters in minor roles. The show's humor is rooted in Larry David's social ineptitude and awkward interactions, not in ridiculing queer identities. While Larry's gaffes can be insensitive, the overall portrayal is incidental, neither strongly affirming nor problematic, as identity is not central to the narrative's comedic thrust.

Curb Your Enthusiasm features trans characters in a few episodes, primarily as catalysts for Larry David's social awkwardness and comedic misunderstandings. The show's humor derives from Larry's discomfort and gaffes when interacting with these characters, rather than directly ridiculing their trans identity. The portrayal is largely incidental, serving the show's established comedic style of satirizing social norms and Larry's inability to navigate them.

Islam is depicted in specific episodes, notably through interactions with Muslim characters and businesses. The show uses these contexts for social and political satire, highlighting human foibles and the absurdity of conflict, without condemning the Islamic faith.

The show extensively portrays Jewish culture and practices, primarily through Larry David's character and his social circle. While it frequently satirizes social hypocrisies, cultural norms, and individual behaviors within the Jewish community, the narrative does not condemn Judaism as a faith. Instead, it uses this rich cultural backdrop to explore universal human foibles and social awkwardness, often positioning Larry's own rigid adherence to his personal code as the source of conflict.