Duckman features a transsexual character in the episode 'Clip Job,' where Bernice transitions to Bernie. The portrayal is largely comedic, deriving humor from the shock and absurdity of the sex change itself. The narrative treats the transition as a source of ridicule rather than exploring the character's identity with dignity or empathy, resulting in a net negative impact.

The show features Bernice, a character with exaggerated physical strength and combat prowess, who consistently defeats multiple male opponents in close-quarters physical combat throughout various episodes.

The show frequently satirizes Christian-adjacent religious figures, particularly televangelists, portraying them as hypocritical, greedy, and manipulative. The narrative critiques the commercialization and abuse of faith, often depicting adherents as easily misled or foolish.