Euphoria provides a complex and raw portrayal of LGBTQ+ characters, notably Jules's transgender journey and Rue's queer relationship. While their experiences are fraught with addiction and trauma, the show depicts their identities and relationships with dignity and depth. Obstacles are framed as external, maintaining an empathetic stance that affirms the worth of their lives and love amidst chaos.

Euphoria features Jules Vaughn, a central transsexual character portrayed with significant depth, agency, and complexity. Her journey explores themes of identity, relationships, and trauma with an empathetic lens, affirming the worth of trans lives and experiences despite the challenges she faces.

The show portrays Christianity primarily through characters who exhibit hypocrisy, performative piety, or struggle under the oppressive weight of conservative religious expectations. It highlights the disconnect between professed values and actions, offering no significant counterbalancing positive portrayal of the faith itself.