Full Frontal with Samantha Bee consistently portrays LGBTQ+ characters and themes in an affirming and supportive manner. The show advocates for LGBTQ+ rights, critiques discrimination, and provides a platform for queer voices, framing obstacles as external forces rather than inherent to identity.

Full Frontal with Samantha Bee consistently portrayed transsexual characters and themes in an affirming light. The show actively critiqued anti-trans legislation and prejudice, while providing respectful platforms for trans voices. Its satirical commentary advocated for dignity, acceptance, and the rights of transgender individuals.

The show frequently satirizes and critiques the political actions, hypocrisy, and discriminatory stances of Christian nationalist movements and conservative religious figures, portraying their use of faith as problematic and often harmful.

The show actively combats Islamophobia, portraying anti-Muslim sentiment as bigoted and unjust, and often highlights the humanity and struggles of Muslim individuals and communities.

The show consistently condemns antisemitism and bigotry against Jewish people, positioning the audience to sympathize with Jewish communities when they are targeted by hate or discrimination.