Good Girls features a significant LGBTQ+ character arc through Annie's child, Ben, who comes out as transgender. The show sensitively portrays Ben's journey of self-discovery and his mother Annie's evolving acceptance and support, ultimately affirming his identity with dignity and empathy.

Good Girls features Beth and Dean's child, Kenny, who expresses a desire to be a girl. The show depicts the parents' initial struggle to understand, followed by a journey of learning and acceptance. The narrative ultimately portrays Kenny's gender identity with dignity and validates their self-expression, framing the family's evolving support as an affirming arc.