Grown-ish offers a primarily positive portrayal of LGBTQ+ characters, notably through Nomi Segal's arc as a bisexual woman. Her identity, relationships, and personal challenges are explored with dignity and complexity, affirming the worth of queer lives and experiences within the show's diverse collegiate setting.

The show features Zaara, a non-binary character, who is depicted with dignity and agency. Her identity is respectfully acknowledged and integrated into the narrative without being a source of ridicule or conflict, contributing to an overall affirming portrayal of transgender themes.

The show explores Christianity primarily through characters' personal relationships with their faith, often depicting struggles with traditional teachings or institutional hypocrisy. However, it generally frames these as individual challenges or critiques of specific interpretations, rather than condemning the religion itself, allowing for nuanced personal journeys.