iZombie includes several minor LGBTQ+ characters whose identities are presented as normal and accepted, without being central to the main narrative. While not deeply affirming, the show avoids negative stereotypes or making queer identity a source of ridicule or tragedy, resulting in an incidental and neutral overall portrayal.

The show "iZombie" features multiple instances of race swapping from its comic book source material. For example, Detective John Jones, a white character in the comic, is portrayed as the Black character Detective Clive Babineaux in the show. Additionally, Liv's white friend Scott from the comic is adapted into the South Asian character Ravi Chakrabarti.

While the show satirizes cults and hypocrisy that appropriate religious language, it generally treats sincere Christian faith and its adherents with respect or as a neutral character trait. The narrative critiques the misuse of faith rather than the faith itself.