KAOS provides a groundbreaking and affirming portrayal of LGBTQ+ characters, naturally embedding queerness into its mythological narrative. All gods are depicted as queer, normalizing diverse identities among powerful figures. The series features a trans-masculine romance with authenticity, presenting queer characters as complex individuals whose identities are integral to their humanity, not defined by struggle. This creates an inclusive and empowering vision.

KAOS portrays Caeneus as a trans man whose identity is intrinsic, not trauma-based. The series emphasizes his journey of self-acceptance, supported by his mother, and features a significant, authentic trans-masculine love story. The narrative avoids reducing his character to his transness, instead depicting him with dignity, complexity, and a central role, affirming trans lives and love with empathy and nuance.

The character Caeneus, originally Caenis and established as female in Greek mythology, is portrayed as trans-masculine (male) in the series. This constitutes a gender swap from the source material.

Several characters from Greek mythology, including Poseidon, Dionysus, Ariadne, and Eurydice, traditionally depicted as ethnically Greek (Mediterranean/Caucasian), are portrayed by actors of Polynesian, South Asian, Middle Eastern, and African descent, respectively. This constitutes multiple instances of race swapping.

While not directly depicted, the series subtly portrays Christian ethics positively. Human characters embodying virtues like compassion and self-sacrifice are contrasted with the corrupt Greek gods, suggesting the narrative aligns with values often associated with Christianity.