Marvel's Luke Cage primarily focuses on themes of race, power, and justice in Harlem. The series does not include any identifiable LGBTQ+ characters or themes, resulting in no specific portrayal to evaluate within its narrative.

Marvel's Luke Cage does not feature any identifiable transsexual characters or themes within its narrative. The series primarily focuses on issues of race, power, and justice in Harlem, with no explicit or implicit portrayal of transgender identities.

All major and supporting characters in Marvel's Luke Cage maintain the same gender as their established comic book counterparts. No instances of a character canonically established as one gender being portrayed as a different gender were identified.

The show primarily features characters who were canonically Black or Latino in the Marvel Comics source material. The casting for major roles, including Luke Cage, Misty Knight, and Mariah Dillard, aligns with their established racial identities, resulting in no race swaps.