Marvel's Luke Cage features a significant bisexual character, Shades Alvarez, whose relationship with Comanche is explored with complexity and emotional depth, treating their same-sex bond as a natural part of their lives. The show avoids negative stereotypes, presenting queer identity with dignity and agency, contributing to a net positive portrayal.

The show features Misty Knight, a detective, who repeatedly engages in and wins close-quarters physical fights against multiple male opponents. Her victories are achieved through skilled hand-to-hand combat, sometimes augmented by a bionic arm.

The film portrays Christianity positively through Luke Cage's strong moral compass, rooted in his pastor father's teachings, and the church's role as a vital community pillar. While some characters from a religious background are corrupt, the narrative clearly condemns their hypocrisy rather than the faith itself, aligning with Christian virtues.