Megamind Rules! does not explicitly feature LGBTQ+ characters or themes in its storyline. The series focuses on superhero adventures and character relationships. While some viewers interpret queer subtext in Megamind's style, this is not an overt portrayal, leading to a net impact of N/A for LGBTQ+ representation.

Based on the available information, there are no detailed accounts of female characters achieving victory in close-quarters physical combat against one or more male opponents. While some female characters are involved in action, their specific combat outcomes against male adversaries are not described as fitting the criteria.

The series features returning characters like Megamind and Roxanne Ritchi, whose on-screen genders align with their established portrayals in the original film. New characters introduced in the series are not considered gender swaps. There is no evidence of any character's gender differing from their source material or established canon.

The series features alien characters where human race is irrelevant. Human characters either maintain their implied race from the original film or are new characters whose casting aligns with their implied ethnicity, thus no established character's race was changed.