Murphy Brown consistently demonstrated a progressive and affirming stance towards LGBTQ+ characters and themes. While earlier depictions were often topical and incidental, they were handled with respect. The 2018 revival further solidified this with the positive and integrated portrayal of a recurring gay character, Pat Patel, contributing to a net positive impact.

The show frequently satirizes and critiques conservative social values, often rooted in specific interpretations of Christianity, portraying their adherents as judgmental, hypocritical, or out of touch. The narrative consistently champions a more liberal, secular perspective, validating these critiques without significant counterbalancing positive portrayals of those specific religious stances.