Ramy features several LGBTQ+ characters, including Ramy's sister Dena exploring a queer relationship, a gay Muslim man named Dennis, and Uncle Naseem discovering his sexuality. The series portrays these characters and their experiences with nuance, empathy, and complexity, exploring their internal conflicts and external challenges within their cultural and religious context. The depiction avoids harmful stereotypes, focusing instead on their dignity and agency.

The series offers a deeply nuanced and often sympathetic portrayal of Islam, focusing on the personal journeys of faith, doubt, and identity for its adherents. It explores the complexities and hypocrisies of its practitioners while affirming the dignity and spiritual seeking inherent in the faith.

The series portrays Judaism with respect and nuance, exploring interfaith relationships and the diversity within Jewish communities. It highlights commonalities and mutual understanding between different faith traditions.