Sacred Games features prominent LGBTQ+ characters, including the transgender Kuckoo and the gay hitman Malcolm Murad. Kuckoo's relationship with Gaitonde offers moments of acceptance and complexity, while Malcolm's villainous role presents a more ambiguous depiction. The show integrates these identities into its dark narrative without a strong overarching positive or negative stance, resulting in a largely neutral net impact.

Sacred Games features Kuckoo, a transsexual woman, as a complex and central character. Her portrayal is largely positive, depicting her with dignity, agency, and a significant role in the narrative. Her relationship with the protagonist is handled with respect, affirming the worth of her life and love despite a tragic outcome, rather than reducing her identity to a source of ridicule or misery.

The film portrays Hindu nationalism and a destructive, cult-like philosophy (Guruji's ideology) that manipulates religious beliefs for power and societal destruction. These elements are central to the antagonist's motivations and are depicted as fundamentally problematic and harmful.

The series prominently features Islamic extremism and terrorism, depicting characters who use religious identity to justify violence and communal conflict. While individual Muslim characters exist, the narrative's focus on radicalized groups and their destructive actions casts a negative light on the portrayal of the religion's role in these conflicts.

The protagonist and his family are Sikh, and their faith is often associated with their moral integrity, sense of duty, and resilience, without being depicted as problematic or extremist.