The Apothecary Diaries does not feature identifiable LGBTQ+ characters or themes. The narrative centers on gender politics and social dynamics in a historical setting, with no noted emphasis on queer representation, resulting in an N/A rating for LGBTQ+ portrayal.

The Apothecary Diaries does not explicitly depict transsexual characters or a transsexual community. While the narrative explores gender nonconformity and challenges traditional gender roles through characters like Jinshi, this is distinct from explicit transsexual representation. The film focuses on broader gender and social dynamics within its historical setting, resulting in no identifiable transsexual themes.

The movie does not contain any action or adventure elements.

The anime adaptation of "The Apothecary Diaries" faithfully portrays the genders of its characters as established in the original light novel and manga. There are no instances where a character canonically established as one gender is depicted as a different gender on screen.

Based on available information and the consistent portrayal of characters as East Asian in both the original light novel and the anime adaptation, no instances of race swapping have been identified.