The Big Bang Theory's portrayal of LGBTQ+ themes is largely problematic. While some non-normative sexual identities are present (e.g., Sheldon's asexuality, Kripke's implied bisexuality), they are either treated incidentally or used for comedic effect, often relying on stereotypes. The presence of homophobic jokes, particularly in earlier seasons, further contributes to a net negative impact, lacking affirming or complex representation.

The show portrays Christianity primarily through Mary Cooper, depicting her faith as sincere, a source of comfort, and a moral compass. While often a comedic contrast to the scientists' atheism, the narrative treats her beliefs with respect and warmth, not condemnation.

Hinduism is portrayed through Raj Koothrappali, highlighting his cultural background, family expectations, and traditions. The show uses these elements for comedic effect, often exploring cultural clashes, but does not portray Hinduism as problematic, instead treating it as a significant part of Raj's identity.

Judaism is depicted through Howard Wolowitz and his family, focusing on cultural traditions and family dynamics. The portrayal is often humorous, satirizing cultural quirks rather than the faith itself, and treats Jewish heritage as a fundamental, positive aspect of the characters' identities.