The Equalizer features LGBTQ+ characters, including a bisexual daughter and a gay team member, whose identities and relationships are consistently portrayed as normal, accepted, and integrated into the narrative without negative stereotyping or conflict arising from their sexual orientation. The show offers an affirming depiction of queer lives.

The Equalizer TV series features a transgender character, Jaden, whose coming out and transition are depicted with sensitivity and affirmation. The narrative focuses on his journey of self-discovery, highlighting the strong support he receives from the main characters, Robyn McCall and her daughter, Delilah, thereby presenting a positive portrayal of transgender identity.

The protagonist of the 2021 series, Robyn McCall, is a female character. This character is a reimagining of Robert McCall, who was canonically male in the original 1980s TV series and subsequent film adaptations.

The lead character, Robert McCall, was originally portrayed as white in the 1980s television series. In the 2021 reboot, the character is reimagined as Robyn McCall, portrayed by a Black actress, constituting a race swap.