The show features LGBTQ+ individuals in various capacities, from family members to professional staff, and generally portrays them with respect. While there are instances of support and acknowledgment, queer identity is not a central theme, nor is it denigrated, resulting in a largely incidental and neutral depiction.

The Kardashians features Caitlyn Jenner, a trans woman, as a recurring family member. Her trans identity is acknowledged as a fact of her life and family dynamic but is not a central theme for narrative exploration. The show neither deeply affirms nor denigrates her identity, treating it as an incidental aspect of her established public persona within the family context.

The show portrays Christianity as a source of comfort, guidance, and moral grounding for several family members. Their expressions of faith, including prayer and references to God, are presented as genuine and supportive aspects of their personal lives, without narrative critique or satire.