The Real Housewives of Atlanta features several LGBTQ+ characters and storylines, notably Cynthia Bailey's daughter coming out as sexually fluid with her mother's support. The show generally portrays LGBTQ+ individuals with dignity and agency as integral parts of the cast's lives, often showcasing evolving acceptance despite occasional initial misunderstandings.

The show featured a transgender woman, Amiyah Scott, who was generally depicted with respect. However, another storyline involved gossip about a transgender woman in relation to a cast member's ex-husband, using her identity as a source of drama. These elements result in a neutral net impact, as positive and negative portrayals largely balance out.

The show frequently depicts Christian characters engaging in conflict, gossip, and materialistic pursuits while simultaneously professing strong faith. The narrative often highlights the perceived hypocrisy and performative aspects of their religious adherence, rather than affirming the virtues or dignity of the faith itself.