TMZ frequently covers LGBTQ+ celebrities and related news as part of its entertainment reporting. The portrayal is largely incidental, presenting queer identity as a factual element of public figures' lives without consistently affirming or denigrating it. The show's focus remains on celebrity gossip, leading to a neutral net impact on LGBTQ+ themes.

TMZ, as a celebrity news program, has covered transsexual individuals and related topics over its run. Its reporting style often prioritizes sensationalism and gossip, which can be intrusive. However, it also reports factual events, resulting in a varied portrayal that is neither consistently affirming nor degrading, leading to a net neutral impact on transsexual themes.

TMZ frequently reports on Christian celebrities involved in scandals or acting hypocritically, often highlighting discrepancies between their stated faith and actions. The show's focus on gossip and controversy rarely provides a counterbalancing positive portrayal of the faith itself, thus contributing to a problematic depiction of its adherents.