Work in Progress centers on the life of a self-identified queer woman navigating relationships, mental health, and daily challenges. The series features a diverse cast of LGBTQ+ characters, including a central relationship with a trans man, depicting their experiences with authenticity and complexity. The narrative offers an affirming and empathetic portrayal of queer identity and relationships.

Work in Progress features an affirming portrayal of transsexual characters and themes. The series introduces Chris, a trans man, as a complex and dignified individual whose identity is explored with nuance and respect. His relationship with Abby is depicted authentically, showcasing a loving connection that normalizes and validates trans experiences without relying on harmful stereotypes. The narrative consistently maintains an empathetic stance towards trans identity.

The series champions progressive family values, celebrating alternative family structures and normalizing queer relationships. It consistently critiques traditional gender roles within its narrative.