Due to the lack of available plot details or character information for the film '45, 2021', an assessment of its portrayal of LGBTQ+ characters or themes cannot be made. There is insufficient data to determine any positive, negative, or neutral impact.

There is insufficient information available about the film '45, 2021' to assess its portrayal of transsexual characters or themes. Details regarding the plot, characters, or narrative focus are not provided, making it impossible to determine any positive, negative, or neutral impact.

The movie does not contain any action or adventure elements.

There is no information provided regarding source material, previous adaptations, or historical figures for the film '45, 2021'. Without a baseline of pre-established characters and their canonical genders, it is impossible to determine if any gender swaps occurred.

The film's nature (original, adaptation, or biopic) is not specified, and no source material or established character races are provided. Without this information, it is impossible to determine if any character's race was changed from a prior depiction.