Annihilation does not feature any identifiable LGBTQ+ characters or themes. The narrative focuses on a scientific expedition into an anomalous zone, exploring themes of mutation, identity, and self-destruction, without incorporating elements related to sexual orientation or gender identity.

Annihilation does not include any explicit transsexual characters or themes. The narrative focuses on scientific exploration, mutation, and the nature of identity within a mysterious anomaly, without engaging with transgender experiences.

The movie does not contain any action or adventure elements.

The film is an adaptation of a novel where the main characters' genders align with their portrayals on screen. No significant character established as one gender in the source material is depicted as a different gender in the film.

The film "Annihilation" is an adaptation of a novel where the races of the main characters were not explicitly specified or visually depicted in the source material. Therefore, the casting choices in the film do not meet the definition of a race swap.