The Rocky Horror Picture Show offers a largely positive portrayal of LGBTQ+ themes through its celebration of sexual liberation, gender fluidity, and non-conformity. Dr. Frank-N-Furter, a charismatic 'transvestite,' serves as the film's central figure, challenging societal norms and guiding other characters through their own awakenings. While the narrative includes tragic elements and morally ambiguous actions, the film's overall tone and enduring cultural impact affirm queer identity and expression.

The Rocky Horror Picture Show features Dr. Frank-N-Furter, a charismatic 'transvestite' from 'Transsexual, Transylvania,' who embodies gender and sexual fluidity. Despite his villainous role and tragic end, his character is celebrated as an icon of self-expression and challenging norms. The film's overall message, through its camp and celebration of 'otherness,' offers a net positive portrayal of transsexual themes.

The film satirizes the repressive and naive aspects of conventional, Christian-influenced morality through characters like Brad and Janet, portraying their initial adherence to these norms as a state from which they need to be liberated.