Mickey 17 offers a positive portrayal of LGBTQ+ characters and themes by integrating visible, non-stereotypical queer relationships organically into its narrative. The film normalizes these relationships and uses its sci-fi elements to metaphorically engage with issues of identity and marginalization relevant to the queer community, affirming their worth and complexity.

The film features Nasha Barridge, a security agent, who actively participates in close-quarters physical combat against male opponents. She is depicted as a formidable soldier, using hand-to-hand and melee weapons, and is generally shown to be victorious or effective in these encounters.

The film critiques Christianity by portraying its imagery and values as manipulated by institutions and individuals for political and colonial ends, justifying exploitation and suppressing revolutionary struggle. It condemns the weaponization of faith rather than the faith itself, highlighting its problematic use to maintain control.